More than 380 million people worldwide are diagnosed with Diabetes. 29 million Americans are diabetic, 1 out of 11 people are affected by diabetes. Diabetic Canadians make 6.8% of the data.
CBD ”ambassadors” are in the focus when it comes to fighting diabetes. The stats provided by the World Health Organization serves the diabetes awareness: By 2030 the number of people with diabetes ailment will be doubled.
If we take a look at the history of diabetes, in the last decade, the number of people diagnosed with diabetes jumped almost 50 percent. This indicates that diabetes is not some kind of ”abstract, mysterious” illness.
Rather, it’s highly caused by the society’s external impacts. Since we know that it’s metabolic disease, by default we conclude that the highest risk of being diagnosed as diabetic is due to the one’s individual lifestyle and nutrition.
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CBD Impact on Diabetes
Even though the public is getting more scared of AIDS or breast cancer, we have more people dying from Diabetes than HIV. No wonder, when even an average medically informed person knows that diabetes causes kidney failure, blindness, amputations, heart failure and stroke.
Before we jump into all scientific, clinical and anecdotal studies, let’s make a conversation starter with the fact that one of the CBD effects and CBD oil benefits, besides the most commonly known CBD pain relief, CBD is known as the natural remedy for diabetes, now the compound has identified as highly effective also from the studying circles.
Laboratory studies: One of the highest quality and trusted studies is the result of many years of research and testing conducted by scientist Raphael Mechoulam and Ruth Gallily from the Hebrew University. This type of research at first clarified that CBD cannot replace the lack of insulin, but it can treat the inflammation caused by the wreck caused by imbalanced sugar in the blood.
The scientists tried to discover how to get in order so the insulin opens the cells and enters the glucose so it can activate the energy that our body needs. Now, distinguishing the Diabetes Type 1, and type 2, the experiments conducted on rats which were treated with CBD, show different results. And it all starts and concludes with the endocannabinoid system.
Cannabinoid receptors have been identified in the pancreas, which automatically means there is its high role in decreasing the severity of diabetes. This is the process in which cannabinoid receptors are the essential part of the pancreas that produces insulin to which body depends on in order to restart the energy.
The study conducted in Israel in 2015, led by Raphael Mechoulam, indicated that the anti-inflammatory properties of cannabidiol could treat both diabetes type 1 and two. Year later, in 2016 the improved research showed that an experimental CBD treatment reduced the markers of inflammation in the microcirculation of the pancreas in mice.
Another important strong evidence extracted from the experiment on the rat is that CBD has a positive impact on decreasing inflammation on pancreatic cells. Focus on the collective researchings: Israeli scientists reveal the interpretation of the results from a study conducted on rats with infarcts (areas of dead tissue) due to a failure of blood supply.
After the CBD treatment, these infarcts were 30 percent smaller. As an autoimmune disease study, published in ‘Autoimmunity Journal’, drafts that injections of 5 mg per day of CBD significantly reduced the level of diabetes in mice.
The same team went beyond this discovery: investigators reported that those mice, in this study 60 percent, who were treated with CBD remained diabetes-free at 26 weeks, in comparing to those who were excluded from the CBD treatment.
How the CBD succeeded in decreasing the inflammation in mice? It’s simply an anti-inflammatory factor because the other experiment on non-obese diabetic mice, where the process was including reducing the plasma levels of pro-inflammatory cytokines and increased levels of anti-inflammatory TH-2 associated cytokines.
Hence the fatal effect of diabetes on the sight, another distinguish study on rodent model at the Medical College of Georgia, discovered that the cannabinoid protected the eye from damaging retinal cell death and the breakdown of the blood-retinal barrier.
Dr. Liou the lead scientist explained, “What we believe cannabidiol does is go in here as an antioxidant to neutralize the toxic superoxides. Number two, it inhibits the self-destructive system and allows the self-produced endogenous cannabinoids to stay there longer by inhibiting the enzyme that destroys them.” Another relevant source is brought by the American Journal of Pathology.
Another relevant source is brought by the American Journal of Pathology. Here also it was shown that CBD treatment on rats so-called “oxidative stress”, including the substance “necrosis factor-a” which is known for acting as the response to the inflammation while protecting the retinal cells from the death.
Clinical Studies: First of all, clinical trials confirmed that both CBD and THC are compounds with ”safe profile” which can effectively treat a metabolic disorder such as diabetes.
Also, it has been confirmed that CBD plays a major role in decreasing and treating both diabetes type 1 and type 2.The UK research team launched a pilot clinical trial to examine the CBD effect in type 2 diabetes patients.of researchers from the UK launched a pilot clinical trial to study their effects in type 2 diabetes patients.
The method which was used was by establishing the placebo-controlled and double-blinded design: The examined group was receiving the dosage of 100 mg twice daily for the duration of 13 weeks. The targets were patients with Diabetes type 2.
The results were quite promising: a change in HDL-cholesterol concentration, insulin sensitivity, body weight, glycemic control, lipid profile, and very important markers of inflammation.
When it comes to diabetes type 1, one of the studies in the US also resulted with the confirmed the notion and turned it into a fact that patients who were treated with cannabis had 16% lower fasting insulin levels, and 17% of insulin resistance. The examined non-users haven’t experienced the same progress. The rest of the studies in this category also endorsed the fact that CBD is a stronger antioxidant than vitamin E or C.
Despite the fact that there are not enough clinical trials, it certainly plays a major role in alleviating the disease and making life easier. For example, it regulates the immune response and it reduces the metabolic inflammation. The British company GW Pharmaceuticals also included CBD in type 2 diabetes.
The results were improved insulin response and greater pancreatic cell function and blood pressure significantly reduced. Another report also goes in favor of CBD intake.
Based in Israel, ISA Scientific has launched a global collaboration and licensing agreement in order to advance CBD therapies. In a statement, ISA Scientific CEO Mark J. Rosenfeld said: “The licensing agreement is very well timed because our Phase 1 clinical trials on dosing and safety are now underway in Israel and arrangements for Phase 2 trials for treating diabetes are in process.”
Unlike insulin, CBD diabetes treatment may actually suppress, and perhaps cure the disease,” Rosenfeld added. From the further statements, CBD diabetes treatment is not the ultimate cure for diabetes, but it has the power to mitigate the symptoms of diabetes.
A study under the name “Marijuana in the Managment of Diabetes” also confirmed that cannabis users are most likely to prevent obesity. Additionally, another finding is that cannabis or CBD users develop “good cholesterol” and have better carbohydrate metabolism than nonusers.
Anecdotal studies have a good tracking record: CBD hemp oil is life-savior and this has been and it is still being confirmed by the strong anecdotal evidence in the collaboration with observational studies which roots for the belief that CBD is highly effective for diabetic patients. The result that the patients find as the most impressive is that CBD is the key factor for establishing the state of homeostasis, in other words, stable internal functioning despite fluctuations in the external environment.
The Time Magazine reports the endorsement by the Harvard Med School researcher Murray Mittleman that current diabetic patients on CBD diabetes treatment witness gradually a normalized blood-sugar level.
Talking about specific places in the US, the doctors in San Francisco Bay Area are known for holding onto more approachable attitude when it comes to their patients who trust CBD diabetes treatment.
CBD Oil Dosage for Diabetes
First and foremost, despite many scientific and clinical research, by the FDA CBD is still approved for sale only as a natural remedy and food supplement. This means that it can not have one official dosage, including also the fact that it treats various illnesses and the diversity of the patients must be considered too.
However, in regard to CBD usage and dosage, anecdotal studies and devoted patient’s approach to CBD diabetes treatment are the relevant sources of information. Anyway, all CBD manufacturers based on their product also put the dosage suggestion on the product itself, but this is a general indication usually aimed at mild issues.
The amount of CBD can be indicated in different ways on the packaging of different brands. Often they indicate the number of milligrams of CBD and the total amount of drops in the bottle. This makes it easy for you to calculate how many drops you need to take your daily dosage. If not, just use our CBD calculator.
Also rather frequently the CBD concentration percentage is indicated, in this case, you have to calculate the total number of milligrams CBD the bottle contains. For example, if the concentration is 20% and you have a 1 gram bottle, the amount of CBD is 20% of 1000 milligrams is 200 milligrams.
On this site, we try to always indicate the dosage amount in milligrams CBD. The number of drops may differ per product because of different concentrations. If you take the number of milligrams as your dosage unity, the concentration basically does not matter. Just for the same milligram dosage, the number of drops will vary.
With very high dosage levels and low concentration oils, you will have to take a lot of drops, so often in these situations, people use higher concentration oils. Besides that almost always, the higher concentration oils are more priceworthy.
The first thing that a patient should consider about CBD diabetes treatment when it comes to dosage is their body weight and severity of the condition. People with low weight need to take less CBD than heavyweights. Just as mild issues require less dosage than severy conditions.
Bellow list is very helpful for patients diagnosed with diabetes type 2:
For Mild diabetes conditions, people usually take 40 to 50 milligram CBD daily and monitor their blood-sugar level. Based on that they either increase, decrease with 10-20 mg steps or keep the same dosage level.
For Severe diabetes conditions, people usually start with 100 or 150 milligrams CBD daily and monitor their blood-sugar level, just like described above. Based on your blood-sugar level you should be able to start decreasing the insulin amounts. Often diabetes patients can completely eliminate insulin intake after gradually having decreased their insulin.
As maintenance dosage, to maintain your health-balance or homeostasis, a dosage of 20 to 25 mg is common. Because it is impossible to overdose CBD, you can safely experiment with the dosage level, monitoring the effects and your blood-sugar level.
General dosage guidelines are as follows:
- Start small.
- Increase if the improvement dynamics are too weak until you see good improvement dynamics.
- Decrease when you see strong improvement dynamics and monitor to keep the same dynamics with less dosage.
- Keep the same dosage level if you see good improvement dynamics and decreasing results in weakening of the dynamics.
To treat glaucoma: a single CBD dose of 20-40 mg under the tongue. Doses greater than 40 mg may actually increase eye pressure.
There are many methods of CBD intake and dosage. The most common way is the form of tincture where CBD should be held first under the tongue to be absorbed in the mouth for at least one minute, before swallowing.
Since diabetes affects the muscles and skin, it can be used as a lotion. Everybody is different, so all these different tips work differently for each individual and everybody can find what works the best for them.
With sublingual intake, some of the CBD taken will be broken down by the digestive system, but most of it will be absorbed by your body directly, shortening the effect lead time. Other oral methods include capsules, mouth strips, and edibles such as chocolate bars. Many people also enjoy using CBD oil via vaporizers or inhalers as this is a near instant delivery method that can be quite effective, but not as long lasting as sublingual and oral intake.
Others use CBD oil by skin absorption via lotions, balms, creams or patches. There are many ways to take CBD oil, what matters most is trying a few different approaches and seeing what works. Again, everyone is different.
Besides CBD a cannabis oil dosage could help, in cases, CBD doesn’t work. With cancer treatment cannabis oil is recommended to be used in a mixture with CBD oil.
Success Stories of Diabetic Patients
The greatest evidence of efficacy is successful patients experiences of CBD diabetes treatment, especially the younger generations who are educating themselves on more natural alternatives, starting and ending with CBD.
There is a chain of doctors who created the CBD advisory network, like Dr. Korey Hood based in the state of California who always advises using CBD or cannabis responsibly, but still, it considers the patients positive CBD experience.
Patients stories as part of anecdotal studies: C.W, a 36 years old man in California who was diagnosed with type 1 diabetes is a living proof that Cannabis and CBD helped him with the complications such as “Diabetic Retinopathy”.
With the advice of a doctor and with an official recommendation by using marijuana this patient took control of his blood sugar and over other diabetic complications. After the treatment, the hypothesis of CBD effects by reducing oxidative stress on the nervous and circulatory systems of a patient has been confirmed as relevant.
The patient encourages other D-affected people to include CBD in their therapy also because it has no negative side effects and overdose manifestation.
Overview of Scientific Studies and Reports
Below is a compilation of scientific research on CBD and depression. The articles are primarily from highly technical scientific journals such as PubMed (U.S. National Library of Medicine). If you ever wondered how CBD can treat depression, check out the studies below.
Scientific Reseach Studies on Diabetes
- 2006 – CBD lowers incidence of diabetes in non-obese diabetic mice
- 2006 – Neuroprotective and blood-retinal barrier-preserving effects of CBD in experimental diabetes
- 2007 – Cannabidiol arrests onset of autoimmune diabetes in NOD mice
- 2008 – The endocannabinoid system in obesity and type 2 diabetes
- 2010 – Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation
- 2010 – Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain
- 2010 – CBD attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
- 2011 – Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes
- 2012 – The endocannabinoid system and plant-derived cannabinoids in diabetes and diabetic complications
- 2013 – Cannabinoids alter endothelial function in the Zucker rat model of type 2 diabetes
- 2014 – Biochemical and immunohistochemical changes in delta-9-tetrahydrocannabinol-treated type 2 diabetic rats
- 2016 – Efficacy and Safety of CBD and THC-V on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes
- 2016 – The impact of marijuana use on glucose, insulin, and insulin resistance among US adults