What are the differences between CBD and CBDa
A recent lab-test showed that CBDa triggers the CB1 receptor whereas CBD does not. This is an indication that CBDa has strong therapeutic qualities. The limited studies on CBDa that have been done so far, indicate that CBDa is less effective than CBD in the proliferation of breast cancer cells.
On the other hand, CBDa proved to be a lot more effective to inhibit COX-2. Therefore combining the two should be more effective, by using the best of both. This is what research studies on CBD for cancer treatment suggest, carried out in 2011 and 2014. It also strengthens the recent trend in believing that a combination of different cannabinoids creates a synergetic effect: Full-Spectrum.
How to use CBD and CBDa?
How is CBD used? There are different ways to take CBD. Most good full-spectrum CBD oils also contain a very small concentration of CBD, but there are also products like Endoca Raw Hemp Oil Paste 3000, that have not been heated and still contain a good amount of CBDa.
You can even take cannabidiol gummies for your daily dosage Cannabidiol Life in our opinion has the best CBD gummies out there.
CBD can be smoked, taken orally (sublingually or drops under the tongue), mixed with food or drinks or even in suppositories or skin care products. The main thing is, is to bring it as close as possible to the ailment. In other words, if you want to use CBD for migraines, it doesn’t make sense to use suppositories.
CBD Comparison tests
Recently we have done several comparison tests, where we ranked the different top CBD brands for conditions like pain and anxiety.
The Best …
Overview of Scientific Studies and Reports
If you are interested in the medical proof and not scared of reading through some professional medical jargon, check out the studies below.
Scientific Research Studies on CBDa
- 2011 – The effects of cannabidiolic acid and cannabidiol on contractility of the gastrointestinal tract of Suncus murinus.
- 2012 – Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration.
- 2013 – Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behavior in rats by enhancing 5-HT1A receptor activation
- 2013 – Suppression of lithium chloride-induced conditioned gaping (a model of nausea-induced behavior) in rats (using the taste reactivity test) with metoclopramide is enhanced by cannabidiolic acid.
- 2013 – Effect of low doses of cannabidiolic acid and ondansetron on LiCl-induced conditioned gaping (a model of nausea-induced behavior) in rats.
- 2014 – Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells
- 2014 – A comparison of cannabidiolic acid with other treatments for anticipatory nausea using a rat model of contextually elicited conditioned gaping.
- 2015 – Effect of combined doses of Δ(9)-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea using rat (Sprague- Dawley) models of conditioned gaping.
- 2015 – Synergy between cannabidiol, cannabidiolic acid, and Δ⁹-tetrahydrocannabinol in the regulation of emesis in the Suncus murinus (house musk shrew).
- 2016 – Effect of combined oral doses of Δ(9)-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea in rat models.
- 2016 – Neuromotor tolerability and behavioral characterization of cannabidiolic acid, a phytocannabinoid with therapeutic potential for anticipatory nausea.